Ongoing Projects :
- Centre of Excellence of Biopharmaceutical Technology
- Modeling based Control of Continuous Manufacturing of Biopharmaceutical Products
- Process Automation and Continuous Process Monitoring Analysis & a Model Based Predictive Control with a view to digitize the Continuous Biopharma Processing
- Surge Tank Management for Continuous Processing
- Deep learning methodologies to develop novel pre-or early cancer detection technology for patients diagnosed with pancreatic cancer
- Managing Charge Variant Profile in Continuous Processing • Translational Research Consortium for Establishing Platform Technologies to Support Prophylactic and Therapeutic Strategies for Dengue ? Discovery to Proof-of-Concept
- Platform for production of affordable biopharmaceuticals: Ranibizumab as a case study
- Development of an economical production process for rHu biosimilar insulin
- Acute decompensated heart failure prediction using Machine Learning algorithm
- Development of ELISA based assay for detection of COVID-19
- Incubator for Bioanalytical Characterization
- Development of peptide based ELISA based assay for detection of COVID-19
- Agilent Thought Leader Award
- Development and evaluation of antigens to capture antibodies on Lateral flow immunoassay device for the screening of COVID-19 infection
Completed Projects (2010-2019) :
- Development of a Low-Cost Therapy for Biological Toxins for Rural India
- Use of Surface Plasmon Resonance for Characterization of Biosimilars
- Modeling of fouling of chromatographic resins (particularly Protein A) during biotherapeutic manufacture
- Creation of an efficient process for purification of monoclonal antibody therapeutics
- Evaluation of CD spectroscopy as a PAT tool for downstream processing
- Determination of aggregation kinetics for monoclonal antibody therapeutics
- Mechanistic modeling for process chromatography
- CFD of mixing in a centrifuge (Culturefuge 100 from Alpha Laval with 3L bowl volume)
- Multivariate data analysis of online data from cell culture processes to correlate concentration of media components to product titre and quality
- QbD based development of downstream process for granulocyte colony stimulating factor (GCSF)
- Evaluation of different PAT strategies for pooling of a process chromatography column
- Evaluation of stability of monoclonal antibody therapeutics under different processing conditions
- Development of a novel aqueous two phase system for clearance of host cell impurities from a therapeutic product expressed in E coli
- Evaluation of CD as a tool for rapid evaluation of stability of monoclonal antibody therapeutics
- CFD simulations for analysing effects of stent design on cerebral aneurysm
- Development of a high throughput process development (HTPD) platform for Predictor plate from GE Healthcare for process chromatography
- Development of a high throughput process development (HTPD) platform for membrane adsorbers from Sartorius Stedim for membrane chromatography
- Creation of a decoupled input-output linearizing controller for enhancing biomass and ethanol production by Saccharomyces cerevisiae
- Use of multivariate data analysis (MVDA) for monitoring and optimization of a membrane separation based desalination plant
- CFD simulations for optimization and scale-up of a helical coil heat exchanger for production of a thermally labile API
- Optimization of a refolding process for a therapeutic protein expressed in Escherichia coli
- Multivariate data analysis of chromatography profiles to assess column performance and predict failures
- Multivariate data analysis of manufacturing data for a biotech therapeutic to establish comparability between two processes
- Establishment of design space for a chromatography step used in purification of a therapeutic protein
- Use of UPLC-MS platform for characterization of E. coli based host cell proteins
- Modeling of viral filtration
- Modeling of microfiltration for harvest of a protein product from fermentation broth
- Development of high throughput process development (HTPD) protocol for use of GE Healthcare’s Predictor Plate based 96 well chromatography system
- Development of high throughput process development (HTPD) protocol for use of Sartorius Stedim’s 96 well membrane adsorber system
- Evaluation of Blitz/Octet devices as PAT tools for protein purification
- Evaluation of CD spectroscopy as a PAT tool for downstream processing
- Determination of aggregation kinetics for monoclonal antibody therapeutics
- CFD of mixing in a bioreactor as a tool for optimization and aid in scale-up (10L, 50L and 300 L)
